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The purpose of this study was to investigate the effects of a protein-free, standardized dialysate/ultrafiltrate (HD) derivatives from calf blood (Solcoseryl) for second-intention full-thickness skin wound healing in dogs. Three 2×2 cm area-matched full-thickness skin wounds were created bilaterally on the dorsolateral aspect of the trunk or nine dogs. In each dog, two wounds were treated with HD, centella asiatica extract (Centrasol) and normal saline, respectively. For six weeks, the wonds were evaluated grossly for contraction, epithlialization and healing and were examined histopathologically. In the first week of the wound healing period, HD stimulated wound contraction and healing more significantly than centasol and normal saline (p<0.05). Neutrophils were more increased in the HD-treated wounds than those in centasol or normal saline treated wonds. In the second week, HD stimulated epithelialization more significantly than centasol or normal saline (p<0.05), and neovascularization and granulation more increased in the HD-treated wounds than those in centaso and normal saline treated wounds. In conclusion, HD was the most effective on early wound contraction, epithlialization and healings among three experimental drugs in full-thickness skin wound.
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